An interference cancellation system (ICS) may be used with a communication system to prevent or minimize interference from one or more sources. The ICS may receive radio frequency (RF) signals comprised of one or more signals of interest (SOI) and multiple interfering signals. An interference estimation processor (IEP) may be used to estimate the one or more interfering signals. The interfering signals may be estimated using spatial and/or time diversity, which may be combined with statistical methods. The estimated interfering signals may be sent to the ICS, which may use the estimated interference signal to cancel the interference and output the SOI.