发明授权
US09345748B2 Anti-SSX-2 T cell receptors and related materials and methods of use
有权
抗SSX-2 T细胞受体及相关材料及使用方法
- 专利标题： Anti-SSX-2 T cell receptors and related materials and methods of use
- 专利标题（中）： 抗SSX-2 T细胞受体及相关材料及使用方法
-
申请号： US13820802申请日： 2011-09-14
-
公开(公告)号： US09345748B2公开(公告)日： 2016-05-24
- 发明人: Richard A. Morgan , Nachimuthu Chinnasamy , Steven A. Rosenberg
- 申请人： Richard A. Morgan , Nachimuthu Chinnasamy , Dhanalakshmi Chinnasamy , Steven A. Rosenberg
- 申请人地址： US DC Washington
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Leydig, Voit & Mayer
- 国际申请： PCT/US2011/051537 WO 20110914
- 国际公布： WO2012/040012 WO 20120329
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K38/17 ; C07K14/725 ; A61K31/706 ; A61K38/08 ; A61K38/10 ; C07K16/28
摘要：
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for synovial sarcoma X Breakpoint (SSX)-2. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.
公开/授权文献
信息查询
