An unequal helix-angle end mill includes a cutting part and a handle part. The cutting part is provided with a plurality of flutes, each spirally extending from the bottom end to the handle part. The face of each flute facing the cutting rotation direction is a rake face, wherein the rake face and an outer peripheral face of the cutting part are intersected to form an outer peripheral blade, and the helix-angle of at least one of the peripheral blades is different from those of the other peripheral blades. A face joined with the peripheral blade among the outer peripheral face of the cutting part is a rear face. The width B of the edge flap of each peripheral blade is equal on a plane orthogonal to a rotating axis of the end mill. The unequal helix-angle end mill has high strength, and enhances the cutting depth and durability.