Invention Grant
US09346798B2 Dihydrobenzoxazine and tetrahydroquinoxaline sodium channel inhibitors
有权
二氢苯并恶嗪和四氢喹喔啉钠通道抑制剂
- Patent Title: Dihydrobenzoxazine and tetrahydroquinoxaline sodium channel inhibitors
- Patent Title (中): 二氢苯并恶嗪和四氢喹喔啉钠通道抑制剂
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Application No.: US14377478Application Date: 2013-02-12
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Publication No.: US09346798B2Publication Date: 2016-05-24
- Inventor: Christiane Boezio , Alessandro Boezio , Howard Bregman , Nagasree Chakka , James R. Coats , Katrina Woodin Copeland , Erin F. Dimauro , Thomas Dineen , Hua Gao , Daniel La , Isaac E. Marx , Hanh Nho Nguyen , Emily Anne Peterson , Matthew Weiss
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Elsa D. Lemoine
- International Application: PCT/US2013/025668 WO 20130212
- International Announcement: WO2013/122897 WO 20130822
- Main IPC: C07D413/12
- IPC: C07D413/12 ; C07D417/12 ; C07D413/14 ; C07D471/04 ; C07D417/14
Abstract:
The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.
Public/Granted literature
- US20150057271A1 DIHYDROBENZOXAZINE AND TETRAHYDROQUINOXALINE SODIUM CHANNEL INHIBITORS Public/Granted day:2015-02-26
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