发明授权
- 专利标题： Trialkyl cationic lipids and methods of use thereof
- 专利标题（中）： 三烷基阳离子脂质及其使用方法
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申请号： US14380536申请日： 2013-02-22
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公开(公告)号： US09352042B2公开(公告)日： 2016-05-31
- 发明人: James Heyes , Mark Wood , Alan Martin
- 申请人： PROTIVA BIOTHERAPEUTICS, INC.
- 申请人地址： CA Burnaby, BC
- 专利权人： PROTIVA BIOTHERAPEUTICS, INC.
- 当前专利权人： PROTIVA BIOTHERAPEUTICS, INC.
- 当前专利权人地址： CA Burnaby, BC
- 代理机构： Viksnins Harris & Padys PLLP
- 国际申请： PCT/US2013/027469 WO 20130222
- 国际公布： WO2013/126803 WO 20130829
- 主分类号： A61K47/18
- IPC分类号： A61K47/18 ; A61K9/14 ; A61K31/713 ; C07C229/12 ; C07C217/08 ; C07C271/20 ; C12N15/113
摘要：
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses.
公开/授权文献
- US20150064242A1 TRIALKYL CATIONIC LIPIDS AND METHODS OF USE THEREOF 公开/授权日：2015-03-05
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