Invention Grant
US09353084B2 2-amino 3,5,5-trifluoro-3,4,5,6-tetrahydropyridines as BACE1 inhibitors for treatment of Alzheimer's disease
有权
2-氨基3,5,5-三氟-3,4,5,6-四氢吡啶作为治疗阿尔茨海默病的BACE1抑制剂
- Patent Title: 2-amino 3,5,5-trifluoro-3,4,5,6-tetrahydropyridines as BACE1 inhibitors for treatment of Alzheimer's disease
- Patent Title (中): 2-氨基3,5,5-三氟-3,4,5,6-四氢吡啶作为治疗阿尔茨海默病的BACE1抑制剂
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Application No.: US14625658Application Date: 2015-02-19
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Publication No.: US09353084B2Publication Date: 2016-05-31
- Inventor: Karsten Juhl , Mauro Marigo , Lena Tagmose , Thomas Jensen
- Applicant: H. Lundbeck A/S
- Applicant Address: DK Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby
- Agency: AuerbachSchrot LLC
- Agent Jeffrey I. Auerbach; William C. Schrot
- Priority: DK201400086 20140219; DK201400349 20140701
- Main IPC: C07D417/12
- IPC: C07D417/12 ; C07D211/72 ; C07D401/12 ; C07D413/12
Abstract:
The present invention is directed to novel inhibitors of the BACE1 enzyme. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders for which the reduction of Aβ deposits is beneficial such as Alzheimer's disease.
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