发明授权
US09353161B2 Streptavidin mutein exhibiting reversible binding for biotin and streptavidin binding peptide tagged proteins
有权
表现出生物素和链霉抗生物素蛋白结合肽标记蛋白的可逆结合的链霉亲和素突变蛋白
- 专利标题： Streptavidin mutein exhibiting reversible binding for biotin and streptavidin binding peptide tagged proteins
- 专利标题（中）： 表现出生物素和链霉抗生物素蛋白结合肽标记蛋白的可逆结合的链霉亲和素突变蛋白
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申请号： US14343883申请日： 2012-09-13
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公开(公告)号： US09353161B2公开(公告)日： 2016-05-31
- 发明人: Sui-Lam Wong , Sau-Ching Wu , Isabelle Barrette-Ng , Kenneth K-S. Ng
- 申请人： Sui-Lam Wong , Sau-Ching Wu , Isabelle Barrette-Ng , Kenneth K-S. Ng
- 申请人地址： unknown Calgary, AB
- 专利权人： UTI LIMITED PARTNERSHIP
- 当前专利权人： UTI LIMITED PARTNERSHIP
- 当前专利权人地址： unknown Calgary, AB
- 代理机构： Parker Highlander PLLC
- 国际申请： PCT/IB2012/002212 WO 20120913
- 国际公布： WO2013/038272 WO 20130321
- 主分类号： C07K14/315
- IPC分类号： C07K14/315 ; C07K17/00 ; C07K14/36 ; C07K1/22 ; G01N33/53
摘要：
The present invention relates to a new streptavidin muteins. This mutein is binds both streptavidin binding peptide tagged and biotin or biotinylated molecules, and does so in a reversible fashion. As such, it is stable enough to allow reuse, and producible with reasonable production yield via secretion in a soluble functional state without the requirement of refolding via the tedious and expensive denaturation and renaturation processes.
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