Mobile computing devices may be equipped with hardware components configured to monitor key assets of the mobile device at a low level (e.g., firmware level, hardware level, etc.). The hardware component may also be configured to dynamically determine the key assets that are to be monitored in the mobile device, monitor the access or use of these key assets by monitoring data flows, transactions, or operations in a system data bus of the mobile device, and report suspicious activities to a comprehensive behavioral monitoring and analysis system of the mobile device. The comprehensive behavioral monitoring and analysis system may then use this information to quickly identify and respond to malicious or performance degrading activities of the mobile device.