Technologies related to dynamic reconfiguration of programmable hardware are generally described. In some examples, coprocessor regions in programmable hardware such as a Field Programmable Gate Array (FPGA) may be dynamically assigned to transition the FPGA from a starting arrangement of coprocessor regions to an efficient arrangement. A placement algorithm may be executed to determine the efficient arrangement, and a path finding algorithm may be executed to determine path finding operations leading from the starting arrangement to the efficient arrangement. The path finding operations may be performed to implement the transition.