Distributed application of enterprise policies to WebRTC interactive sessions, and related methods, systems, and computer-readable media are disclosed. In this regard, in one embodiment, a method for applying an enterprise policy to a WebRTC interactive session comprises receiving, by a distributed policy enforcement agent of a recipient device, a WebRTC session description object directed to the recipient device originating from a sender device via a secure network connection. The method further comprises determining, by the distributed policy enforcement agent, one or more enterprise policies based on the WebRTC session description object. The method additionally comprises applying the one or more enterprise policies to the WebRTC session description object. In this manner, an enterprise may permit establishment of a WebRTC interactive session that crosses an enterprise network boundary, while at the same time ensuring that the WebRTC interactive session complies with the one or more enterprise policies.