Invention Grant
US09364452B2 Pharmaceutical composition for preventing or treating hepatic fibrosis and cirrhosis containing ramalin
有权
用于预防或治疗含有马马隆的肝纤维化和肝硬化的药物组合物
- Patent Title: Pharmaceutical composition for preventing or treating hepatic fibrosis and cirrhosis containing ramalin
- Patent Title (中): 用于预防或治疗含有马马隆的肝纤维化和肝硬化的药物组合物
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Application No.: US14381490Application Date: 2012-02-29
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Publication No.: US09364452B2Publication Date: 2016-06-14
- Inventor: Joung Han Yim , Il Chan Kim , Se Jong Han , Hyoung Seok Lee , Hari Datta Bhattarai , Su-Geun Yang , Lee Don Hang
- Applicant: Joung Han Yim , Il Chan Kim , Se Jong Han , Hyoung Seok Lee , Hari Datta Bhattarai , Su-Geun Yang , Lee Don Hang
- Applicant Address: KR Gyeonggi-Do
- Assignee: KOREA INSTITUTE OF OCEAN SCIENCE AND TECHNOLOGY
- Current Assignee: KOREA INSTITUTE OF OCEAN SCIENCE AND TECHNOLOGY
- Current Assignee Address: KR Gyeonggi-Do
- Agency: Hultquist, PLLC
- Agent Steven J. Hultquist
- Priority: KR10-2012-0020515 20120228
- International Application: PCT/KR2012/001519 WO 20120229
- International Announcement: WO2013/129714 WO 20130906
- Main IPC: A61K31/165
- IPC: A61K31/165 ; A23L1/30 ; A61K36/09

Abstract:
There is provided a novel use of ramalin for preventing or treating liver diseases, and more specifically, a pharmaceutical composition for preventing or treating hepatic fibrosis or cirrhosis containing ramalin or a pharmaceutically acceptable salt thereof, and a functional food containing the same. It was confirmed that at the time of applying ramalin, which is a compound derived from Ramalina terebrata according to the present invention, to animal models, ramalin may remarkably suppress hepatic fibrosis and lower liver cirrhosis levels as compared to silymarin known as a liver cell protecting ingredient without cytotoxicity to normal liver cells, such that ramalin may be effectively used for preventing or treating hepatic fibrosis and liver cirrhosis.
Public/Granted literature
- US20150031771A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING HEPATIC FIBROSIS AND CIRRHOSIS CONTAINING RAMALIN Public/Granted day:2015-01-29
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