A power control system and method to mitigate interference in a heterogeneous network is provided. A power control method to mitigate interference may include: receiving a link connection request from a femto terminal; transmitting a downlink signal when the link connection request is allowed; receiving information of a macro terminal present around a femto base station; controlling a power of the downlink signal in response to a high interference indicator (HII) report being included in the received information of the macro terminal; and controlling the power of the downlink signal based on a priority of service while satisfying predetermined constraints, in response to the HII report in a state in which the power of the downlink signal is decreased up to a predetermined required power.