发明授权
US09370531B2 Method of providing patient specific immune response in amyloidoses and protein aggregation disorders
有权
在淀粉样变性和蛋白质聚集障碍中提供患者特异性免疫应答的方法
- 专利标题： Method of providing patient specific immune response in amyloidoses and protein aggregation disorders
- 专利标题（中）： 在淀粉样变性和蛋白质聚集障碍中提供患者特异性免疫应答的方法
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申请号： US12733437申请日： 2008-09-01
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公开(公告)号： US09370531B2公开(公告)日： 2016-06-21
- 发明人: Karsten Henco , Roger Nitsch , Jan Grimm , Anja Zeller , Marcel Maier
- 申请人： Karsten Henco , Roger Nitsch , Jan Grimm , Anja Zeller , Marcel Maier
- 申请人地址： US NY New York
- 专利权人： New York University
- 当前专利权人： New York University
- 当前专利权人地址： US NY New York
- 代理机构： LeClairRyan, a Professional Corporation
- 优先权： EP07017135 20070831
- 国际申请： PCT/EP2008/007127 WO 20080901
- 国际公布： WO2009/027105 WO 20090305
- 主分类号： A61K45/00
- IPC分类号： A61K45/00 ; A61K39/00 ; C12N15/117 ; A61K31/7088 ; A61K39/39
摘要：
A treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed against pathological protein aggregates or neo-epitopes present on pathogenic forms of said protein or protein complex. Furthermore, therapeutic methods are also described, wherein ex vivo stimulated antigen-selected peripheral blood lymphocytes are regrafted into the cognate donor.
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