Invention Grant
- Patent Title: Fluorescent metal ion indicators with large stokes shifts
- Patent Title (中): 荧光金属离子指示器具有大的斯托克斯位移
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Application No.: US14307445Application Date: 2014-06-17
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Publication No.: US09372181B2Publication Date: 2016-06-21
- Inventor: Kyle Gee , Vladimir Martin
- Applicant: LIFE TECHNOLOGIES CORPORATION
- Applicant Address: US CA Carlsbad
- Assignee: Life Technologies Corporation
- Current Assignee: Life Technologies Corporation
- Current Assignee Address: US CA Carlsbad
- Main IPC: G01N23/00
- IPC: G01N23/00 ; G01N33/20 ; C07C229/18 ; C07D221/14 ; C07D265/38 ; C07D311/82 ; C09B5/60 ; C09B5/62 ; C09B11/06 ; G01N33/84 ; C07D209/14 ; C07D311/90 ; C07D413/04

Abstract:
The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the reporter moiety (fluorophore or fluorescent protein) and spacer or linker between the sensing and reporter moieties of the present compound that allows for PET upon binding of a metal ion and excitation by an appropriate wavelength.
Public/Granted literature
- US20140363824A1 Fluorescent Metal Ion Indicators with Large Stokes Shifts Public/Granted day:2014-12-11
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