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US09372181B2 Fluorescent metal ion indicators with large stokes shifts 有权
荧光金属离子指示器具有大的斯托克斯位移

Fluorescent metal ion indicators with large stokes shifts
Abstract:
The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the reporter moiety (fluorophore or fluorescent protein) and spacer or linker between the sensing and reporter moieties of the present compound that allows for PET upon binding of a metal ion and excitation by an appropriate wavelength.
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