发明授权
- 专利标题： Antibodies directed against ICOS and uses thereof
- 专利标题（中）： 针对ICOS的抗体及其用途
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申请号： US14008423申请日： 2012-03-29
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公开(公告)号： US09376493B2公开(公告)日： 2016-06-28
- 发明人: Julien Faget , Christophe Caux , Christine Menetrier-Caux , Jacques Nunes , Daniel Olive
- 申请人： Julien Faget , Christophe Caux , Christine Menetrier-Caux , Jacques Nunes , Daniel Olive
- 申请人地址： FR Paris FR Marseilles FR Marseilles FR Villeurbanne FR Lyons
- 专利权人： INSERM (Institut National de la Sante et de la Recherche Mediacale),INSTITUT JEAN PAOLI & IRENE CALMETTES,UNIVERSITE D'AIX-MARSEILLE,UNIVERSITE CLAUDE BERNARD,CENTRE LEON BERARD
- 当前专利权人： INSERM (Institut National de la Sante et de la Recherche Mediacale),INSTITUT JEAN PAOLI & IRENE CALMETTES,UNIVERSITE D'AIX-MARSEILLE,UNIVERSITE CLAUDE BERNARD,CENTRE LEON BERARD
- 当前专利权人地址： FR Paris FR Marseilles FR Marseilles FR Villeurbanne FR Lyons
- 代理机构： McAndrews, Held & Malloy, Ltd.
- 优先权： EP11305380 20110331
- 国际申请： PCT/EP2012/055735 WO 20120329
- 国际公布： WO2012/131004 WO 20121004
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K39/395 ; G01N33/569
摘要：
The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNγ production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.
公开/授权文献
- US20140086923A1 Antibodies Directed Against ICOS and Uses Thereof 公开/授权日：2014-03-27