- 专利标题: Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof
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申请号: US14741645申请日: 2015-06-17
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公开(公告)号: US09381192B2公开(公告)日: 2016-07-05
- 发明人: John Hood , David Mark Wallace , Sunil Kumar KC
- 申请人: Samumed, LLC
- 申请人地址: US CA San Diego
- 专利权人: Samumed, LLC
- 当前专利权人: Samumed, LLC
- 当前专利权人地址: US CA San Diego
- 代理机构: Fish & Richardson P.C.
- 主分类号: A61K31/437
- IPC分类号: A61K31/437 ; A61K31/444 ; A61K31/4545
摘要:
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases due to mutations in Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
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