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US09381232B2 Nano-recombinant fibrinogen for fibrin sealants 有权
用于纤维蛋白封闭剂的纳米重组纤维蛋白原

Nano-recombinant fibrinogen for fibrin sealants
Abstract:
A fibrin-based hemostatic agent suitable for both civilian and military use is disclosed. The hemostatic agent comprises (i) nanoparticles to which a plurality of Knob-A recognition sequences are attached, and (ii) coiled-coils of recombinantly-produced human fibrinogen α and chains and the γ chain globular domain. A delivery system for the hemostatic agent also is disclosed, which additionally comprises means for delivering (i) and (ii) to a wound site. The delivery means may be a CO2 canister or a shaker jet.
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