Invention Grant
- Patent Title: Azabenzimidazole tetrahydropyran derivatives
- Patent Title (中): 偶氮苯并咪唑四氢吡喃衍生物
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Application No.: US14419842Application Date: 2013-08-16
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Publication No.: US09382243B2Publication Date: 2016-07-05
- Inventor: James M. Apgar , Tesfaye Biftu , Ping Chen , Danqing Feng , Jacqueline D. Hicks , Ahmet Kekec , Kenneth J. Leavitt , Bing Li , Iyassu Sebhat , Xiaoxia Qian , Lan Wei , Robert R. Wilkening , Zhicai Wu
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Baerbel R. Brown; Catherine D. Fitch
- International Application: PCT/US2013/055240 WO 20130816
- International Announcement: WO2014/031465 WO 20140227
- Main IPC: C07D471/02
- IPC: C07D471/02 ; A61K31/00 ; C07D471/04 ; A61K31/366 ; A61K31/397 ; A61K31/4985 ; A61K31/437 ; A61K31/444 ; A61K45/06
Abstract:
Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
Public/Granted literature
- US20150210685A1 NOVEL AZABENZIMIDAZOLE TETRAHYDROPYRAN DERIVATIVES Public/Granted day:2015-07-30
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