Invention Grant
US09382331B2 Alpha-enolase specific antibodies and methods of uses in cancer therapy
有权
α-烯醇酶特异性抗体及其在癌症治疗中的应用
- Patent Title: Alpha-enolase specific antibodies and methods of uses in cancer therapy
- Patent Title (中): α-烯醇酶特异性抗体及其在癌症治疗中的应用
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Application No.: US14142186Application Date: 2013-12-27
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Publication No.: US09382331B2Publication Date: 2016-07-05
- Inventor: Shih-Chong Tsai , Neng-Yao Shih , Ta-Tung Yuan , Ko-Jiunn Liu , Shih-Chi Tseng , Chih-Yung Hu , Hsin-Yun Wang , Li-Tzong Chen
- Applicant: Development Center for Biotechnology , National Health Research Institutes
- Applicant Address: TW New Taipei TW Miaoli County
- Assignee: Development Center for Biotechnology,National Health Research Institutes
- Current Assignee: Development Center for Biotechnology,National Health Research Institutes
- Current Assignee Address: TW New Taipei TW Miaoli County
- Agency: Osha Liang LLP
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/40 ; G01N33/574 ; A61K39/00
Abstract:
The present invention discloses an anti-human alpha-enolase (ENO1) antibody, which can bind the peptides, comprising amino-acid sequence 296FD Q D D W G A W Q K F TA309 (SEQ ID: #9) and/or 326K R I A K A V N EK S336 (SEQ ID: #10) of human ENO1 protein (GenBank: AAH50642.1), has a favorable binding activity (the binding affinity is around 2.19×10-10 mol/L) and a remarkable capability to inhibit the cell invasion and tumor metastasis of a varied of tumors. The recognized peptides and antibody of the invention are useful for diagnosis, prognosis, and treatment of cancers that have been reported to express cell-surface ENO1 such as including lung, breast, pancreas, liver, colorectal, prostate cancers and solid tumors.
Public/Granted literature
- US20150183884A1 ALPHA-ENOLASE SPECIFIC ANTIBODIES AND METHODS OF USES IN CANCER THERAPY Public/Granted day:2015-07-02
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