Embodiments are directed to a self-reference STT-MRAM sensing scheme that uses offset-cancellation to reduce the impact of FET mismatch and thereby allow the sensing of lower read voltages. In some embodiments, the sensing scheme includes a differential amplifier having a first input connected to a memory cell. In some embodiments, a second input of the differential amplifier may be connected to ground, a common mode voltage of the system or a mid-level supply voltage. The present disclosure provides flexibility with respect to the voltage level at which the sensing is performed (e.g., ground, Voc, Vmid, etc.). The present disclosure provides further flexibility with respect to the sense voltage polarity.