Invention Grant
- Patent Title: Inhibitor compounds of phosphodiesterase type 10A
- Patent Title (中): 磷酸二酯酶10A型抑制剂化合物
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Application No.: US14029142Application Date: 2013-09-17
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Publication No.: US09388180B2Publication Date: 2016-07-12
- Inventor: Hervé Geneste , Michael Ochse , Karla Drescher , Clarissa Jakob , Maricel Torrent
- Applicant: Abbott GmbH & Co. KG , AbbVie Inc.
- Applicant Address: US IL North Chicago DE Wiesbaden
- Assignee: AbbVie Inc.,Abbott GmbH & Co. KG
- Current Assignee: AbbVie Inc.,Abbott GmbH & Co. KG
- Current Assignee Address: US IL North Chicago DE Wiesbaden
- Agency: Neal Gerber & Eisenberg LLP
- Main IPC: C07D491/14
- IPC: C07D491/14 ; C07D495/14 ; C07D498/14 ; C07D513/14 ; A61K31/4985 ; A61P25/18 ; A61P25/24 ; A61P25/28 ; A61P25/30 ; A61P3/04 ; C07D471/14 ; C07D491/04 ; C07D495/04 ; C07D498/04

Abstract:
The present invention relates to compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof. where in formula I the variables X, Y, Q1, Q2 have the following meanings: X is C—R3 or N; Q1 is S or O and Q2 is C—R4 or N and Q2 is connected to X via a double bond while Q1 is connected to X via a single bond; or Q2 is S or O and Q1 is C—R4 or N and Q1 is connected to X via a double bond while Q2 is connected to X via a single bond; Y is C—R5 or N; where in formula I the variables R1, R2, R3, R4 and R5 are as defined in the claims The compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.
Public/Granted literature
- US20140107126A1 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A Public/Granted day:2014-04-17
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