A remote seal assembly for subsea applications is provided. The assembly includes an upper housing having a fluid coupling for coupling the remote seal to a process fluid pressure measurement device. A lower housing is coupled to the upper housing and has an interface that is configured to mount to a pressure vessel. The lower housing also has a process fluid inlet. An isolation diaphragm is disposed between the upper and lower housings. At least one of the upper housing, lower housing and isolation diaphragm are constructed from a material suitable for immersion in saltwater. In some embodiments, the lower housing has a shoulder disposed about the process fluid inlet and a plurality of self-energizing seals configured to couple the assembly to a venturi flow meter body. A subsea process fluid flow measurement system is also provided that includes a pressure transmitter and at least one subsea remote seal assembly.