Disclosed herein are methods and systems for dynamically adjusting frequency offsets for mitigating interference. One embodiment takes the form of a process carried out by a mobile radio configured to use an adjustable transmit frequency. The mobile radio estimates an expected base-station-receive power level with respect to transmissions from to a base station. The mobile radio adjusts the transmit frequency to be a center frequency of a radio channel plus a default frequency offset responsive to the estimated expected base-station-receive power level being less than a first threshold. The mobile radio adjusts the transmit frequency to be the center frequency plus a modified frequency offset responsive to the estimated expected base-station-receive power level being greater than a second threshold. The modified frequency offset is greater in magnitude than the default frequency offset. The mobile radio transmits an uplink signal to the base station over the adjusted transmit frequency.