Interference cancellation techniques may be implemented in a radio transceiver configured to transmit a radio-frequency transmit signal at a transmit frequency and having two or more local oscillators operative to simultaneously generate local oscillator signals, at corresponding local oscillator frequencies, for simultaneously down-converting two or more corresponding received radio-frequency signals. An example method begins with identifying one or more self-interfering frequencies, based on the local oscillator frequencies and the transmit frequency. A baseband cancellation signal is then generated by weighting and frequency-shifting a baseband representation of the transmit signal, based on the identified self-interfering frequencies. The baseband cancellation signal is then combined with a down-converted received signal, to obtain an interference-reduced baseband signal.