发明授权
- 专利标题： Amides as pim inhibitors
- 专利标题（中）： 酰胺作为抑制剂
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申请号： US14380918申请日： 2013-02-27
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公开(公告)号： US09394297B2公开(公告)日： 2016-07-19
- 发明人: Victor Cee , Frank Chavez, Jr. , Jian J. Chen , Essa Hu Harrington , Bradley Herberich , Claire L. M. Jackson , Brian A. Lanman , Thomas T. Nguyen , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian L. Smith , Nuria A. Tamayo , Andrew Tasker , Hui-Ling Wang , Bin Wu , Ryan Wurz
- 申请人： AMGEN INC.
- 申请人地址： US CA Thousand Oaks
- 专利权人： AMGEN INC.
- 当前专利权人： AMGEN INC.
- 当前专利权人地址： US CA Thousand Oaks
- 代理商 Bernard P. Friedrichsen
- 国际申请： PCT/US2013/028087 WO 20130227
- 国际公布： WO2013/013066 WO 20130906
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D471/04 ; C07D487/04
摘要：
The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
公开/授权文献
- US20150329538A1 AMIDES AS PIM INHIBITORS 公开/授权日：2015-11-19
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