发明授权
- 专利标题： Carbocycle-substituted purine and 7-deazapurine compounds
- 专利标题（中）： 碳替代嘌呤和7-脱氮嘌呤化合物
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申请号： US13991145申请日： 2011-12-05
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公开(公告)号： US09394310B2公开(公告)日： 2016-07-19
- 发明人: Edward J. Olhava , Richard Chesworth , Kevin W. Kuntz
- 申请人： Edward J. Olhava , Richard Chesworth , Kevin W. Kuntz
- 申请人地址： US MA Cambridge
- 专利权人： Epizyme, Inc.
- 当前专利权人： Epizyme, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Cooley LLP
- 代理商 Heidi A. Erlacher; Lian Ouyang
- 国际申请： PCT/US2011/063289 WO 20111205
- 国际公布： WO2012/075492 WO 20120607
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D473/34
摘要：
The present invention relates to carbocycle-substituted purine and 7-deazapurine compounds of Formula (I). The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof.