发明授权
US09394526B2 FROG/TOAD conditionally silenced vectors for hypoxia gene therapy
有权
FROG / TOAD有条件地沉默低氧基因治疗载体
- 专利标题: FROG/TOAD conditionally silenced vectors for hypoxia gene therapy
- 专利标题(中): FROG / TOAD有条件地沉默低氧基因治疗载体
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申请号: US13504438申请日: 2010-11-01
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公开(公告)号: US09394526B2公开(公告)日: 2016-07-19
- 发明人: Keith A. Webster
- 申请人: Keith A. Webster
- 申请人地址: US FL Miami
- 专利权人: University of Miami
- 当前专利权人: University of Miami
- 当前专利权人地址: US FL Miami
- 代理机构: Wolf, Greenfield & Sacks, P.C.
- 国际申请: PCT/US2010/054929 WO 20101101
- 国际公布: WO2011/053896 WO 20110505
- 主分类号: A61K48/00
- IPC分类号: A61K48/00 ; C12N7/00 ; C07K14/515 ; C07K14/52 ; C12N15/85 ; C12N15/86 ; A61K31/7088
摘要:
Methods and compositions for the treatment of hypoxia associated disorders by directional angiogenesis/arteriogenesis. Conditionally silenced vectors expressing a therapeutic molecule under hypoxic conditions avoid chaotic vascularization and allow for the orderly growth of new vessels into damaged tissue.