Provided are systems and methods for microphone signal fusion. An example method commences with receiving a first and second signal representing sounds captured, respectively, by internal and external microphones. The second signal includes at least a voice component. The first signal and the voice component are modified by at least human tissue. The first and second signals are processed to obtain noise estimates. The first signal is aligned with the second signal. The second signal and the aligned first signal are blended based on the noise estimates to generate an enhanced voice signal. The internal microphone is located inside an ear canal and sealed for isolation from acoustic signals outside the ear canal. The external microphone is located outside the ear canal. All of parts of the processing, blending and aligning of the systems and method may be performed on a subband basis in the frequency domain.