The present invention provides a relay-based foolproof circuit for over-voltage protection, which is electrically connected between a plug and an electric device, and includes a relay having at least one magnetic core, a coil wound around the magnetic core and two reed switches each having a reed and being normally in a closed state because of the elastic effect of its reed. The relay-based foolproof circuit is able to provide AC power of a first specification (e.g., 110 V AC power) received from the plug to the electric device. However, when AC power of a second specification (e.g., 220 V AC power) greater than the first specification flows through the coil, the coil causes the magnetic core to generate a magnetic force great enough to drive the two reed switches into an open state for stopping the AC power of the second specification from being provided to the electric device.