发明授权
US09409916B2 Piperidinone carboxamide spirohydantoin CGRP receptor antagonists
有权
哌啶酮甲酰胺螺乙内酰脲CGRP受体拮抗剂
- 专利标题： Piperidinone carboxamide spirohydantoin CGRP receptor antagonists
- 专利标题（中）： 哌啶酮甲酰胺螺乙内酰脲CGRP受体拮抗剂
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申请号： US14005673申请日： 2012-03-14
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公开(公告)号： US09409916B2公开(公告)日： 2016-08-09
- 发明人: Ian M. Bell , Justin Belardi
- 申请人： Ian M. Bell , Justin Belardi
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 H. Eric Fischer; John C. Todaro
- 国际申请： PCT/US2012/028973 WO 20120314
- 国际公布： WO2012/129013 WO 20120927
- 主分类号： C07D487/10
- IPC分类号： C07D487/10 ; C07D471/10
摘要：
The present invention is directed to piperidinone carboxamide spirohydantoin derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.