发明授权
- 专利标题: Particulate composition and pharmaceutical composition containing the same
- 专利标题(中): 颗粒组成和含有它的药物组合物
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申请号: US13381841申请日: 2010-08-31
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公开(公告)号: US09415059B2公开(公告)日: 2016-08-16
- 发明人: Yasuki Kato , Atsushi Ishii
- 申请人: Yasuki Kato , Atsushi Ishii
- 申请人地址: JP Kashiwa
- 专利权人: Nanocarrier Co., Ltd.
- 当前专利权人: Nanocarrier Co., Ltd.
- 当前专利权人地址: JP Kashiwa
- 代理机构: Lewis Roca Rothgerber Christie LLP
- 优先权: JP2009-200681 20090831
- 国际申请: PCT/JP2010/064816 WO 20100831
- 国际公布: WO2011/025036 WO 20110303
- 主分类号: A61K38/16
- IPC分类号: A61K38/16 ; A61K31/7088 ; A61K9/107 ; A61K9/127 ; A61K31/715 ; A61K38/38 ; C12N15/88
摘要:
The present invention provides a particulate composition containing: block copolymer units being arranged radially with hydrophobic polymer-chain segments radially inside and hydrophilic polymer-chain segments radially outside; and a charged lipid which carries a charge opposite to the charge of a drug to be encapsulated, the charged lipid being attracted to the hydrophobic polymer-chain segment. In this particulate composition, the drug is retained within the particle via electrostatic binding with the charged lipid, whereby the outer surface of the particle is prevented from being charged to attract a substance which has a charge opposite to that of the charged lipid.
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