A device for opening and emptying filled two-piece capsules, each having a capsule lower part and a capsule upper part, comprises a separator block for separating the capsule lower part from the capsule upper part. A guide pusher is provided for pressing individual two-piece capsules into the separator block in a pressing direction. The separator block has a first clamping track for the lower capsule part and a second clamping track for the capsule upper part. The clamping track have a direction of advancement in which the capsule upper part or capsule lower part can be moved by the guide pusher and be clamped perpendicularly thereto. The two clamping tracks are inclined such that their directions of advancement diverge at an angle to the pressing direction of the guide pusher.