发明授权
- 专利标题： Jagged-binding agents and uses thereof
- 专利标题（中）： 锯齿结合剂及其用途
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申请号： US14572321申请日： 2014-12-16
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公开(公告)号： US09416178B2公开(公告)日： 2016-08-16
- 发明人: Austin L. Gurney , Timothy Charles Hoey , Aaron Ken Sato , Alexandra Lazetic , Zhimin Ji
- 申请人： OncoMed Pharmaceuticals, Inc.
- 申请人地址： US CA Redwood City
- 专利权人： OncoMed Pharmaceuticals, Inc.
- 当前专利权人： OncoMed Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Redwood City
- 代理机构： Sterne, Kessler, Goldstein & Fox PLLC
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/04 ; C12N5/10 ; C12N5/12 ; C12N15/13 ; C07K16/28 ; C07K16/18 ; A61K39/395 ; A61K39/00
摘要：
The present invention relates to Jagged-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind to an extracellular domain of human Jagged1 or human Jagged2 and modulate Jagged activity. The present invention further provides methods of using agents that modulate the activity of Jagged, such as antibodies that specifically bind Jagged, and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
公开/授权文献
- US20150197561A1 JAGGED-BINDING AGENTS AND USES THEREOF 公开/授权日：2015-07-16
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