Embodiments of the present invention disclose a lightning protection radio remote unit RRU, which includes a primary circuit, a secondary circuit, and a working circuit, where the primary circuit and the secondary circuit are configured to convert a power supply output by a power supply system into a working power supply to power the working circuit; the shield layer located on the RRU side of the shielded cable and the shield layer located on the power supply system side of the shielded cable are grounded respectively; a surge over-voltage withstand capability between the primary circuit and the earth is not less than a lightning over-voltage; a surge over-voltage withstand capability between each inner conductor in the shielded cable and the shield layer of the shielded cable is not less than the lightning over-voltage.