Methods, a base station and computer programs for performing multiple access in wireless OFDM cellular systems over multipath wireless channels considering both space and frequency domains,The base station 100 comprises a large number of antennas 103 in the form of a two-dimensional array and transmits a given number of signals to a number of users 106, so that each one receives its intended signal (or set of intended signals) without interference to/from the other users 106. The base station 100 includes a scheduler in space-time-frequency dimensions 101 as well as an orthogonal space-frequency processing technique 102 for addressing the users 106. The cellular scenario is assumed where the wireless channel 105 presents significant multipath, thereby resulting in multiple signal components being received by each user 106. Orthogonality of the beams is achieved upon transmission by properly discretizing the spatial domain, while inter-user interference is avoided by exciting only those beams that result in multipath components received by one single user 106.