A multi-rank memory module is operable in a memory system with a memory controller. The memory module according to one embodiment comprises at least one module board, memory devices organized in three ranks, and at least one register device providing control/address signals to the memory devices. Arrangement of the ranks on the at least one module board are made to balance memory device loadings on the C/A signals, and data/strobe signal hubs are designed to provide better alignment of different data bits in a data signal and to reduce reflection from discrete components disposed near an edge of the module board, resulting in improved signal quality and integrity.