发明授权
US09428491B2 Substituted azoles, antiviral active component, pharmaceutical composition, method for preparation and use thereof
有权
取代的唑类，抗病毒活性成分，药物组合物，其制备方法和用途
- 专利标题： Substituted azoles, antiviral active component, pharmaceutical composition, method for preparation and use thereof
- 专利标题（中）： 取代的唑类，抗病毒活性成分，药物组合物，其制备方法和用途
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申请号： US13990428申请日： 2011-11-28
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公开(公告)号： US09428491B2公开(公告)日： 2016-08-30
- 发明人: Alexandre Vasilievich Ivachtchenko , Vadim Vasilievich Bichko , Oleg Dmitrievich Mitkin
- 申请人： Alexandre Vasilievich Ivachtchenko , Vadim Vasilievich Bichko , Oleg Dmitrievich Mitkin
- 优先权： RU2010148813 20101130
- 国际申请： PCT/RU2011/000932 WO 20111128
- 国际公布： WO2012/074437 WO 20120607
- 主分类号： C07D403/14
- IPC分类号： C07D403/14 ; C07D403/04 ; C07D409/14 ; C07D405/14 ; C07D413/14
摘要：
The present invention relates to novel antiviral active 5-{4-[1H-imidazol-5-ylaryl(or hetaryl)]-buta-1,3-diynyl}-1H-imidazoles of the general formula 1 and pharmaceutically acceptable salt thereof, pharmaceutical composition, antiviral medicament, therapeutic kit for prophylaxis and treatment of hepatisis C virus diseases, and method for prophylaxis and treatment of hepatisis C. wherein: R1 and R2—represent optionally identical radicals selected from 2.1 and 2.2, where an asterisk (*) denotes the position of attachment to the imidazole fragment, (S) and (R) are types of chiral centers; R3 is isopropyl or phenyl radicals; Ar an aromatic or heteroaromatic diradical.
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