Invention Grant
US09434719B2 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
有权
3-嘧啶-4-基 - 恶唑烷-2-酮作为突变体IDH的抑制剂
- Patent Title: 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
- Patent Title (中): 3-嘧啶-4-基 - 恶唑烷-2-酮作为突变体IDH的抑制剂
-
Application No.: US14408418Application Date: 2014-03-12
-
Publication No.: US09434719B2Publication Date: 2016-09-06
- Inventor: Thomas Raymond Caferro , Zhuoliang Chen , Young Shin Cho , Abran Q. Costales , Julian Roy Levell , Gang Liu , James R. Manning , Martin Sendzik , Cynthia Shafer , Michael David Shultz , James Sutton , Yaping Wang , Qian Zhao
- Applicant: Thomas Raymond Caferro , Zhuoliang Chen , Young Shin Cho , Abran Q. Costales , Julian Roy Levell , Gang Liu , James R. Manning , Martin Sendzik , Cynthia Shafer , Michael David Shultz , James Sutton , Yaping Wang , Qian Zhao
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent Rona Nardone
- International Application: PCT/IB2014/059695 WO 20140312
- International Announcement: WO2014/141104 WO 20140918
- Main IPC: C07D413/04
- IPC: C07D413/04 ; A61K31/506 ; C07D413/14 ; C07D417/14 ; A61K31/5377
Abstract:
The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
Public/Granted literature
- US20150152093A1 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH Public/Granted day:2015-06-04
Information query
