A system and method to defragment a memory is disclosed. In a particular embodiment, a method includes loading data stored at a first physical memory address of a memory from the memory into a cache line of a data cache. The first physical memory address is mapped to a first virtual memory address. The method further includes initiating modification, at the data cache, of lookup information associated with the first virtual memory address so that the first virtual memory address corresponds to a second physical memory address of the memory. The method also includes modifying, at the data cache, information associated with the cache line to indicate that the cache line corresponds to the second physical memory address instead of the first physical memory address.