Flow control devices and methods of using the flow control devices are provided. In a general embodiment, the present disclosure provides a cassette (30) comprising a housing (32) having a constrictor (34), a tube (36) attached to the housing and positioned through the constrictor, and a ball positioned inside the tube. The constrictor can be constructed and arranged to prevent the ball (38) from moving through the tube at the location proximate the constrictor. The ball can prevent fluid flow in one position and be dislodged to allow fluid flow when the cassette is positioned inside a pumping device. As a result, the cassette is designed to prevent free flow of fluid when an enteral feeding tube set is not installed in a pumping device.