A control device for internal combustion engine mounted in a vehicle includes a throttle valve provided in an intake passage of the internal combustion engine and capable of changing a cross-sectional area of the intake passage, a variable valve capable of changing opening and closing timings of an intake valve of the internal combustion engine, basic target torque calculation means for calculating a basic target torque of the internal combustion engine according to an operating state of the internal combustion engine, vibration control target torque calculation means for calculating a vibration control target torque of the internal combustion engine to suppress vehicle vibration according to a vibration component of the vehicle, and cylinder intake air amount control means for controlling a cylinder intake air amount by controlling one of the throttle valve and the variable valve according to the vibration control target torque and controlling the other of the throttle valve and the variable valve according to the basic target torque.