Invention Grant
- Patent Title: PRMT1 inhibitors and uses thereof
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Application No.: US14212965Application Date: 2014-03-14
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Publication No.: US09447079B2Publication Date: 2016-09-20
- Inventor: Lorna Helen Mitchell , Gideon Shapiro , Richard Chesworth , Paula Ann Boriack-Sjodin , Oscar Miguel Moradei , Kevin Wayne Kuntz
- Applicant: Epizyme, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Epizyme, Inc.
- Current Assignee: Epizyme, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D405/12 ; C07D231/12 ; A61K31/415 ; A61K31/455
Abstract:
Described herein are compounds of Formula (I-a) and (I-b), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT1 activity. Methods of using the compounds for treating PRMT1-mediated disorders are also described.
Public/Granted literature
- US20140288129A1 PRMT1 INHIBITORS AND USES THEREOF Public/Granted day:2014-09-25
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