Invention Grant
US09447101B2 Pyrrolo[2,1-f][1,2,4]triazine compound, and preparation method and application thereof
有权
吡咯并[2,1-f] [1,2,4]三嗪化合物及其制备方法和应用
![Pyrrolo[2,1-f][1,2,4]triazine compound, and preparation method and application thereof](/docs/US/2016-09-20/US09447101B2/abs.jpg.600x600.jpg)
- Patent Title: Pyrrolo[2,1-f][1,2,4]triazine compound, and preparation method and application thereof
- Patent Title (中): 吡咯并[2,1-f] [1,2,4]三嗪化合物及其制备方法和应用
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Application No.: US14403014Application Date: 2013-04-23
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Publication No.: US09447101B2Publication Date: 2016-09-20
- Inventor: Chunhao Yang , Linghua Meng , Yanhong Chen , Xiang Wang , Cun Tan , Jiapeng Li , Jian Ding , Yi Chen
- Applicant: Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai Haihe Pharmaceutical Co., Ltd.
- Applicant Address: CN Shanghai CN Shanghai
- Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Shanghai Haihe Pharmaceutical Co., Ltd.
- Current Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Shanghai Haihe Pharmaceutical Co., Ltd.
- Current Assignee Address: CN Shanghai CN Shanghai
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: CN201210177980 20120531
- International Application: PCT/CN2013/074559 WO 20130423
- International Announcement: WO2013/177983 WO 20131205
- Main IPC: C07D419/04
- IPC: C07D419/04 ; C07D419/14 ; A61K31/5377 ; A61K31/5386 ; A61K31/53 ; A61P35/00 ; C07D487/04 ; C07D519/00 ; C07D498/08
![Pyrrolo[2,1-f][1,2,4]triazine compound, and preparation method and application thereof](/abs-image/US/2016/09/20/US09447101B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a pyrrolo[2,1-f][1,2,4]triazine compound, an isomer thereof or a pharmaceutically acceptable salt, ester or hydrate thereof, and a preparation method and application thereof. The pyrrolo[2,1-f][1,2,4]triazine compound has a structure expressed in general formula (I). The pyrrolo[2,1-f][1,2,4]triazine compound expressed in general formula (I) can inhibit a phosphatidylinositol-3 kinase (PI3K) signal pathway, thereby being used to prepare medicine for treating phosphatidylinositol-3 kinase related diseases such as cancer.
Public/Granted literature
- US20150141644A1 PYRROLO[2,1-F][1,2,4]TRIAZINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF Public/Granted day:2015-05-21
Information query
