Invention Grant
- Patent Title: Mass spectrometry method for a polypeptide including a cysteine residue
- Patent Title (中): 包含半胱氨酸残基的多肽的质谱法
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Application No.: US13576124Application Date: 2011-03-28
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Publication No.: US09448241B2Publication Date: 2016-09-20
- Inventor: Jumpei Naito , Shuya Satoh , Manabu Komatsu , Hiroyuki Hashimoto
- Applicant: Jumpei Naito , Shuya Satoh , Manabu Komatsu , Hiroyuki Hashimoto
- Applicant Address: JP Tokyo
- Assignee: CANON KABUSHIKI KAISHA
- Current Assignee: CANON KABUSHIKI KAISHA
- Current Assignee Address: JP Tokyo
- Agency: Fitzpatrick, Cella, Harper & Scinto
- Priority: JP2010-077842 20100330; JP2011-065780 20110324
- International Application: PCT/JP2011/058474 WO 20110328
- International Announcement: WO2011/122692 WO 20111006
- Main IPC: G01N33/68
- IPC: G01N33/68 ; H01J49/00
Abstract:
The problem to be solved by the present invention is to provide a method for treating a polypeptide including a cysteine residue for enhancing the sensitivity of detection thereof in mass spectrometry using charged particles. A mass spectrometry method for a polypeptide including a cysteine residue is provided which includes treating the polypeptide including a cysteine residue with a cyanation agent, treating the cyanated polypeptide with a base, and then desorption ionizing the base-treated polypeptides using charged particles for mass spectrometry.
Public/Granted literature
- US20120301968A1 MASS SPECTROMETRY METHOD Public/Granted day:2012-11-29
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