A system for loading and unloading a cargo compartment of a vehicle, such as an aircraft, with a cargo receiving device is provided. The system includes a cargo receiving device including a base structure arrangement having a horizontal lower contact surface, and a locking mechanism configured to engage one or more corresponding holding members provided in a cargo compartment of a vehicle. The system also includes a transport device including a horizontal upper contact surface configured to be disposed in abutting contact to said lower contact surface, a drive unit configured to initiate horizontal movement of the transport device, a lift unit configured to initiate vertical movement of the upper contact surface, and an actuating unit configured to actuate the locking mechanism of the cargo receiving device.