- 专利标题： Complement pathway modulators and uses thereof
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申请号： US14408216申请日： 2013-06-19
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公开(公告)号： US09452990B2公开(公告)日： 2016-09-27
- 发明人: Michael Dechantsreiter , Jonathan E. Grob , Aengus Macsweeney , Wolfgang Miltz , Stefan Andreas Randl , Richard Sedrani , Holger Sellner , Finton Sirockin , Eric Valeur
- 申请人： Michael Dechantsreiter , Jonathan E. Grob , Aengus Macsweeney , Wolfgang Miltz , Stefan Andreas Randl , Richard Sedrani , Holger Sellner , Finton Sirockin , Eric Valeur
- 申请人地址： CH Basel
- 专利权人： NOVARTIS AG
- 当前专利权人： NOVARTIS AG
- 当前专利权人地址： CH Basel
- 代理商 John B. Alexander
- 国际申请： PCT/US2013/046644 WO 20130619
- 国际公布： WO2013/192345 WO 20131227
- 主分类号： C07D239/95
- IPC分类号： C07D239/95 ; C07D403/12 ; C07D401/14 ; C07D413/14 ; C07D401/12 ; C07D403/04 ; C07D403/14 ; C07D405/12 ; C07D409/12 ; A61K31/517 ; A61K31/5377
摘要：
The present invention provides a compound of formula I a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitor of the complement alternative pathway and particularly as inhibitor of Factor B for the treatment of e.g. age-related macular degeneration and diabetic retinopathy. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
公开/授权文献
- US20150126492A1 Complement Pathway Modulators and Uses Thereof 公开/授权日：2015-05-07
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