Invention Grant
US09457073B2 Live attenuated replication-competent arteriviruses having decreased dub/deisgylating activity
有权
活的减毒复制能力的动脉病毒具有降低的配体/解异活性
- Patent Title: Live attenuated replication-competent arteriviruses having decreased dub/deisgylating activity
- Patent Title (中): 活的减毒复制能力的动脉病毒具有降低的配体/解异活性
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Application No.: US14035415Application Date: 2013-09-24
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Publication No.: US09457073B2Publication Date: 2016-10-04
- Inventor: Marjolein Kikkert , Brian Leonard Mark , Puck Bertyne van Kasteren , Terrence William James , Eric John Snijder
- Applicant: Leiden University Medical Center , University of Manitoba
- Applicant Address: CA Winnipeg
- Assignee: University of Manitoba
- Current Assignee: University of Manitoba
- Current Assignee Address: CA Winnipeg
- Priority: EP12186162 20120926
- Main IPC: A61K39/12
- IPC: A61K39/12 ; A61K39/42 ; A61K9/02 ; C12N7/00 ; A61K39/02 ; A61K39/40 ; A61K39/00
Abstract:
The present invention relates to replication-competent Arteriviruses having a decreased DUB/deISGylating activity due to a mutation in the PLP2 domain of the non-structural protein nsp2, to their use as a medicament, their use as a vaccine and in prophylaxis, to vaccines comprising such Arteriviruses and to Arteriviral PLP2-ubiquitin complexes.
Public/Granted literature
- US20140154265A1 ARTERIVIRUS Public/Granted day:2014-06-05
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