Invention Grant
US09458110B2 Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors
有权
苯基吡唑衍生物作为有效的ROCK1和ROCK2抑制剂
- Patent Title: Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors
- Patent Title (中): 苯基吡唑衍生物作为有效的ROCK1和ROCK2抑制剂
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Application No.: US14770500Application Date: 2014-02-28
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Publication No.: US09458110B2Publication Date: 2016-10-04
- Inventor: Mimi L. Quan , Zilun Hu , Cailan Wang , Peter W. Glunz
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu
- International Application: PCT/US2014/019237 WO 20140228
- International Announcement: WO2014/134388 WO 20140904
- Main IPC: C07D231/12
- IPC: C07D231/12 ; C07D401/12 ; C07D417/12 ; C07D403/12 ; C07D217/12 ; C07D405/12 ; C07D513/04 ; C07D231/56 ; C07D413/12
Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
Public/Granted literature
- US20160016910A1 PHENYLPYRAZOLE DERIVATIVES AS POTENT ROCK1 AND ROCK2 INHIBITORS Public/Granted day:2016-01-21
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