Invention Grant
- Patent Title: Phenoxypropanol derivative and pharmaceutical composition including the same
- Patent Title (中): 苯氧基丙醇衍生物和包含其的药物组合物
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Application No.: US14361844Application Date: 2012-11-30
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Publication No.: US09458120B2Publication Date: 2016-10-04
- Inventor: Eun-Joo Roh , Kye-Jung Shin , Changjoon Justin Lee , Soo Jin Oh , Jung-Eun Park , Jeong Eun Yang , Eun Mi Hwang , Dong Ho Woo , Soon-Hyouk Lee , Dong-Gyu Kim , Hee-jung Chun , Wan-Keun Ji , Yun-Soo Na
- Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Applicant Address: KR Seoul
- Assignee: KORBA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee: KORBA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee Address: KR Seoul
- Agency: Goldilocks Zone IP Law
- Priority: KR10-2011-0127053 20111130
- International Application: PCT/KR2012/010322 WO 20121130
- International Announcement: WO2013/081420 WO 20130606
- Main IPC: C07D295/15
- IPC: C07D295/15 ; A61K31/496 ; C07D295/088 ; C07D231/40 ; C07D211/22 ; C07D211/38 ; C07D211/52 ; C07D211/58 ; C07D233/64 ; C12N5/071 ; C07D401/04 ; C07D403/06 ; C07D413/04 ; A61K31/495 ; A61K31/454 ; A61K31/4545 ; A61K31/5377

Abstract:
The present invention relates to a novel phenoxypropanol derivative, represented by the structure of Chemical Formula I, and a racemate thereof, a pharmaceutically acceptable salt thereof, a solvate thereof and a hydrate thereof, wherein * represents an (R)-form or an (S)-form, X is selected from the group consisting of hydrogen, halogen and substituted or unsubstituted straight or branched alkyl having 1 to 4 carbon atoms, and n represents the number of X and an integer of 1 to 5, wherein at least a hydrogen is substituted with halogen in the substituted linear or branched alkyl having 1 to 4 carbon atoms. The derivative can be used for blocking T-type calcium channel and/or TREK channel, and for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.
Public/Granted literature
- US20150166496A1 DERIVATIVES OF 1-PHENOXY PROPAN-2-OL AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME Public/Granted day:2015-06-18
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