Invention Grant
- Patent Title: Bicyclic sulfonamide compounds as sodium channel inhibitors
- Patent Title (中): 双环磺酰胺化合物作为钠通道抑制剂
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Application No.: US14920833Application Date: 2015-10-22
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Publication No.: US09458152B2Publication Date: 2016-10-04
- Inventor: Matthew Weiss , Alessandro Boezio , Christiane Boezio , John R. Butler , Margaret Yuhua Chu-Moyer , Erin F. Dimauro , Thomas Dineen , Russell Graceffa , Angel Guzman-Perez , Hongbing Huang , Charles Kreiman , Daniel La , Isaac E. Marx , Benjamin Charles Milgram , Hanh Nho Nguyen , Emily Anne Peterson , Karina R. Vaida , Brian Sparling
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Elsa D. Lemoine
- Main IPC: A61K31/00
- IPC: A61K31/00 ; C07D417/14 ; C07D471/04 ; C07D413/12 ; C07D401/12 ; C07D413/14 ; C07D417/12 ; C07C53/18 ; C07D215/227 ; C07D403/12 ; C07D215/36 ; C07D241/44 ; C07D401/14
Abstract:
The present invention provides compounds of Formula I, and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders and itch. Also provided are pharmaceutical compositions containing compounds of the present invention.
Public/Granted literature
- US20160046626A1 BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS Public/Granted day:2016-02-18
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